According to a hypothesis of central sensitization, long-term pain sensitizes central nervous system, even if the pain is nociceptive pain or peripheral neuropathic pain. Pain due to sensitized central nervous system is central neuropathic pain. It is impossible that chronic pain is nociceptive pain alone. Therefore, chronic pain is neuropathic pain alone or combination of nociceptive pain and neuropathic pain.
Pharmacological treatment of neuropathic pain is similar regardless of each disease except trigeminal neuralgia, complex regional pain syndrome, and attack of migraine and cluster headache, etc. In all likelihood, disease (or syndrome) whose number of medicine with evidence (more than 1 randomized controlled study) is the greatest, is fibromyalgia. Therefore, pharmacological treatment of fibromyalgia is effective for major part of pain. Based on my experience, pharmacological treatment of fibromyalgia is effective for major part of pain.
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